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Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane [Score: 100%]
Author / Editor: Kaether, Christoph; Haass, Christian |  Place of publication: New York, NY |  Publisher: Rockefeller University Press |  Year of Publication: 2002 | 11 s.
Journal / Series / Collection: The journal of cell biology; 158
Subject Area: Biologie; Chemie und Pharmazie; Medizin
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Amyloid beta-peptide is produced by cultured cells during normal metabolism; 6393 [Score: 100%]
Author / Editor: Haass, Christian |  Place of publication: London |  Publisher: Nature Publishing Group |  Year of Publication: 1992 | 4 s.
Journal / Series / Collection: Nature; 359
Subject Area: Chemie und Pharmazie; Biologie
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Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases; 11 [Score: 100%]
Author / Editor: Steiner, Harald; Haass, Christian |  Place of publication: London |  Publisher: Nature Publishing Group |  Year of Publication: 2000 | 4 s.
Journal / Series / Collection: Nature cell biology; 2
Subject Area: Biologie
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Reconstitution of gamma-secretase activity; 5 [Score: 100%]
Author / Editor: Edbauer, Dieter; Haass, Christian |  Place of publication: London |  Publisher: Nature Publishing Group |  Year of Publication: 2003 | 3 s.
Journal / Series / Collection: Nature cell biology; 5
Subject Area: Biologie
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Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch; 4 [Score: 100%]
Author / Editor: Capell, Anja; Haass, Christian |  Place of publication: London |  Publisher: Nature Publishing Group |  Year of Publication: 2000 | 7 s.
Journal / Series / Collection: Nature cell biology; 2
Subject Area: Biologie
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The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity; 24 [Score: 100%]
Author / Editor: Kaether, Christoph; Haass, Christian |  Place of publication: London |  Publisher: Nature Publishing Group |  Year of Publication: 2004 | 11 s.
Journal / Series / Collection: The EMBO journal; 23
Subject Area: Biologie; Chemie und Pharmazie
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Presenilins mediate a dual intramembranous gamma-secretase cleavag of Notch-1; 20 [Score: 100%]
Author / Editor: Okochi, Masayasu; Haass, Christian |  Place of publication: London |  Publisher: Nature Publishing Group |  Year of Publication: 2002 | 9 s.
Journal / Series / Collection: The EMBO journal; 21
Subject Area: Biologie; Chemie und Pharmazie
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A gamma-secretase-like intramembrane cleavage of TNFAlpha by the GxGD aspartyl protease SPPL2b; 8 [Score: 100%]
Author / Editor: Fluhrer, Regina; Haass, Christian |  Place of publication: London |  Publisher: Nature Publishing Group |  Year of Publication: 2006 | 3 s.
Journal / Series / Collection: Nature cell biology; 8
Subject Area: Biologie
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